Characterization of human parainfluenza virus type 3 persistent infection in cell culture

Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells.

Human parainfluenza virus type 3 (HPIV-3) is an airborne pathogen that infects human lung epithelial cells from the apical (luminal) plasma membrane domain. In the present study, we have identified cell surface-expressed nucleolin as a cellular cofactor required for the efficient cellular entry of HPIV-3 into human lung epithelial A549 cells. Nucleolin was enriched on the apical cell surface do...

Kawasaki disease associated with parainfluenza type 3 virus infection.

Kawasaki disease (KD) is an acute, febrile and multisystem vasculitis of early childhood with a striking predilection for the coronary arteries. In developed countries, the incidence of KD has replaced acute rheumatic fever as the leading cause of acquired heart disease in children. The etiologic agent of KD remains unknown, although clinical and epidemiologic features strongly indicate an infe...

The Enigma of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Infection in Iran

Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy.  The prevalence of HTLV-I infection varies significantly in different regions of the world.  In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained.  HTLV-1 antibody assay on serum samples was d...

Human Parainfluenza Virus Type 3 in Wild Nonhuman Primates, Zambia

Human parainfluenza virus type 3 (HPIV3) genome was detected in 4 baboons in Zambia. Antibody for HPIV3 was detected in 13 baboons and 6 vervet monkeys in 2 distinct areas in Zambia. Our findings suggest that wild nonhuman primates are susceptible to HPIV3 infection.

Study of the Association Between Human T-cell Lymphotropic Virus Type I Infection and Lichen Planus